The best antivirus / anti malware is preventing ever getting it in the first place. Theres so much newer malware and viruses that antivirus programs don't yet have signatures for which makes them largely undetectable.
Just be safe, don't download stuff from places or people you don't trust, be really careful before running or installing anything, dont open random emails/attatchments, be careful what you click/download and even of some pages you visit that can have malicious scripts when browsing the internet. Be VERY careful about clicking RUN and YES when it asks you if you want to run or allow something to run.
If you do all that - you shouldn't really need antivirus or antimalware. If those things detect any REAL malware then it's likely your system has hundreds or thousands of undetected malware/viruses anyways.
Smart to keep all your important files and stuff on an external hard drive and every so often just reformat your pc and reinstall everything.
I burned all my software, a copy of windows, and the latest drivers/driver updates onto dvds so when I reformat its just a matter of installing stuff one by one, instead of having to redownload everything. Reformatting really is the best (only?) way to ensure your system is truly safe.