Yes, it's all over.  

Just as you can never step into the same stream twice;  that water has gone somewhere else.  The Bitcoin of yesterday is gone, and only the Bitcoin of today remains.  Well, except for the entire existing blockchain that has remained the same for years, but then new blocks get added every day.  So it stays the same, except for the new parts which make it different.  Except that the previous blocks never change.  But other than that, it's all over.  And also it's just beginning.  Bitcoin is dead, long live Bitcoin.