Yes, all mine are on CX750's, total of 8 S5s running 400mhz, lowest is 1210 gh/s highest is 1300 gh/s. Does seem to make a small difference on most but a couple of my miners throw way less errors at 375 and still mine in the 1200 gh/s range, just play with the settings on each to see what works best for each miner.