There are alt currencies that won't be affected by ASIC.   I've no idea what the profitability level is, but if you have paid-for GPUs and phenomenally inexpensive electricity (or free), then mining a scrypt-based crypto currency wouldn't be all that radical of a shift.

But with the Bitcoin difficulty rising thanks to new capacity from FPGAs coming online, the day may come that GPUs are no longer good for bitcoin mining even before the ASICs ship.  Fortunately the incease in the exchange rate has more than exceeded the rise in difficulty, but it could be that difficulty will rise even faster going forward.

 - http://blockchain.info/charts/miners-operating-profit-margin