I'm pretty sure it's a hard thing to run a online casino from within the US if that's what you're asking. Most gambling sites that I know operate from outside. It was also pretty dubious to use these sites from within the US but that situation may have changed recently, I don't know.
Forget running online casinos from the US, even allowing US customers to access your offshore casino can be problematic.
Satoshidice and Luckybit block IP addresses from the US from gambling on their sites.
https://www.cryptocoinsnews.com/bitcoin-gambling-site-satoshibet-turns-back-united-states-market/