Easy.
Step 1. Go on a dice site
Step 2. Deposit 2 BTC
Step 3. Play on x2 multiplier settings
Step 4. Roll!
Hey, you asked for the best way... It wasn't going to be the safest way. Those two just simply don't mix.
LOL.... pretty good. although i'd say that the "best" way probably means the "safest" way. to the OP's question (old as it is), it really depends on your skills. my best bet personally is to manage my risk in trading bitcoin and forex. it's worked out pretty well so far.

gambling is very lucrative, and very easy to get the money there if you are really lucky, but if you're not lucky, you could lose all bitcoin that you have and it only happens in a few minutes, think again if you want to gamble