Yes, lost coins are lost coins. Nothing you can do about it. Bitcoin is divisible to 8 places so there is plenty for everyone. Why we wouldn't be talking in satoshis term one day, not in Bitcoin terms. 1 satoshi can be worth $1 and everybody would be happy.

Because of this above, I don't think there will be consensus rules about changing the final supply. I wouldn't like that the total supply changes.

Now what will future bring us, that nobody knows!