I've been in-sync for several hours, mining, and I have even restarted the machine several times for equipment/driver installation.

I haven't lost any information... and I have over 1200 coins in my wallet.

Win 7 x64
Xeon L5640
24GB DDR3 2400 (@1600 8-8-8-29)
Radeon R9 290 4GB
Radeon 7870 2GB

8500cpm during mining.

Currently fighting with heat... that's the only issue I run into.