^^ You should talk to my uncle. He lives in Argentina now but lived in the Brazilian amazon for a year or so and took ayahuasca with the local natives.
I've been considering DMT for a while now. I've tried lsd, mushrooms and salvia and they were all pretty fun and had me in a definitely spiritual state of mind but nothing near what DMT can do, id imagine. When winter comes around and the stress from making enough coin before the paycut dies down i might mingle with some cubes again.
The only other psychedelic I've tried before was mushrooms (though I've experienced them many times). Though there are clear similarities, the level of the experience is incomparable. On mushrooms I generally always had one hand in this material plane. With ayahuasca, the material plane was just gone (albeit for a much shorter timeframe than mushrooms). The movie Atlas posted (spirit molecule) is pretty informative about the experiences. I haven't experienced what many of those people have (yet), but plan to go to ceremonies with stronger doses soon.