Well there are a lot of things, and I'm not sure where to start. As far as changes are concerned, we've yet to see what is going to come out of the block size debate (i.e. are we going with a increase in blocksize or sidechains, lightning network or something else). We should see pruning implemented completely (hopefully) in the next major version (0.12?), which is partially implemented now.
We've yet to see Gemini exchange released (Winklevoss), which should be fully regulated and built on rock-solid compliance.

Adoption and investments keep growing and we can not really know where this will lead us. We are yet to see a big online retailer such as Ebay or Amazon to start accepting Bitcoin (which some of us are eager to see). The block reward should also halve in 2016 (July 27th).