I got 1xiano.... in about 2 hours on a relatively poor GPU.
If you use vanityminer (64 bit if you can), you can use regular expressions.  Means you can search case sensitive and it doesn't have to be at the beginning (infact, I couldn't find a way to put it at the beginning)

Using regex
[Xx][Ii][Aa][Nn][Oo]
i found a match in about 5 mins, even with the lower rate of using RegEx.  Sadly you can only use CPU for this!

Alex