My U3 are like my cats, they need a bit of attention but most of the time they're fine.
I don't think that the occasionnal zombie is a problem (well, unless it's a cat then it'll eat you while you sleep)

How many do you have? When I had 3 on windows i caused multiple times a day of attention.
The worst ones were if I was not around it sit there zombied, and no hashing. CrazyGuy's R1 really is great at fixing zombies.
I have 6 running on a RPI2
(Clic to enlarge)

I monitor them nearly constantly (using cryptoglance) when I'm working from home, and when cgminer doesn't manage to restart the occasionnal zombie, I get to unplug/plug the USB cable.
it happens 2/3 times a day. (and not 2/3 times per U3, but generally)
I have 3 running on the power adapter and 3 on a 650W power supply that also runs my BFL30Ghs and 4 fans.
I've ordered shorter USB cable so I don't have to loop them as I'm doing with the long ones coming with the U3.
I'm running mine connected to an integrated USB hub in my monitor with a 2 m cable and a 550 W ATX PSU. So when it zombies I don't have to replug the cables, just flip the PSU switch and push a button on the monitor.
It bothers me though if it is safe to leave it for a long time unattended. I mean, can it possibly fail so badly that it catches fire and burns the apartment? Do you guys take any precautions just in case?