In theory, yes. Investing in a well reputable dice site, for example, should be +EV if you are near 100% that is has a sufficient bankroll to deal with swings, and will never just take off and run after first signs of trouble. Its still going to be a very low ROI investment, %-wise.

Making your own site is a whole different thing and is probably about 100x harder to achive, as it would require a ton more money to do so, not to mention gathering a competent group of people to work with.