The safest way to win from gambling is to be the house or invest in the house.
Though there is a bigger chance of winning when you are an investor, there are still situation when your investment gone smaller because someone played and win big in the site that you have invested your coins in, so still not safe..
well, investing is investing, still better than gambling. there are reliable methods for safe investing, not like bunch of methods try to be safe of gambling but never exist any reliable one.