CG drawing is a very different creature.
My ones are done by first doing the outline (vectoring) of the objects then colouring and shading and touching up and adding effects ... in graphic layers.
... and you can cheat ... undo

Though, that's not all that different in concept to how one would normally draw a picture, work out scales with basic curves and lines and then go into details.
But vectoring it on a computer is indeed very different.
I do have a graphics tablet but only once ever tried to use it.
The mouse wins for me.

But whatever you find easiest is of course best - vector drawing like I've done is so different that it takes quite a while to work out how to do it.

I did about one of those pics per week for a couple of years and got better as time went on.
Here's a simple one - this is where I 'extracted' the green eye from for the top left on the web site.
I liked drawing anime eyes
http://kano-kun.net/a/Aki-chanCh5Pg122.png
The basics of how I start is like this:
http://kano-kun.net/a/Aki-chanCh5Pg122-Lines.jpg
Vectored over an original (usually crappy scan quality due to the low quality of some manga paper) B&W manga image.