Got another mining question for the experts!

Is there an advantage or disadvantage to plotting small chunks on larger drives versus one large plot taking up the whole drive?

I have a couple 2TB drives but only have 1 large plot on each taking up the whole drive but unable to use the plot optimizer due to no space now that I found that it increases speed by 15-20mb/s. Is there any speed or deadline difference if u have a 2TB plot versus 2 1TB's or even 4 500gb's using a single drive? I'd like to ideally have 1 drive just to plot say 500gb plots then optimize them and move them to larger drives filling them up with the smaller chunks of plots.

Hope my question makes sense and someone knows the answer and can help me squeeze the most out of my small 8tb setup, thanks!