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They reach a point where the core developers have betrayed the white paper of Satoshi. The power of mining has gone to large corporations
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most users should start running client-only software and only the specialist server farms keep running full network nodes, kind of like how the usenet network has consolidated.
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The design outlines a lightweight client that does not need the full block chain.  In the design PDF it's called Simplified Payment Verification.  The lightweight client can send and receive transactions, it just can't generate blocks.  It does not need to trust a node to verify payments, it can still verify them itself.
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I anticipate there will never be more than 100K nodes, probably less.  It will reach an equilibrium where it's not worth it for more nodes to join in.  The rest will be lightweight clients, which could be millions.

At equilibrium size, many nodes will be server farms with one or two network nodes that feed the rest of the farm over a LAN.

The current system where every user is a network node is not the intended configuration for large scale.  That would be like every Usenet user runs their own NNTP server.  The design supports letting users just be users.  The more burden it is to run a node, the fewer nodes there will be.  Those few nodes will be big server farms.  The rest will be client nodes that only do transactions and don't generate.
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