It's kind of a moot point - giving a gambler $ 50M will only encourage them to gamble more heavily while an occasional gambler who only buys the local lottery for a couple of dollars isn't going to go out and corner the market for sweep-stake tickets in one draw, no matter how many systems they can dream up.
A better question would have been
If I give you $ 50 Million, how would you gamble it?
You could also research online for those who have actually won multi million dollar lottery prizes and see how it had affected them and their families.