BTC Guild started setting up a new server this morning running modified block rules.  Currently trying out a 500,000 byte maxblocksize.  The problem is with larger blocks, you increase the chance of orphans since it will take at least twice as long to propagate, if not more.  I've modified the fee settings to prefer fee based transactions when increasing the block size past 50 KB, so hopefully the increase in fees per block offset the orphan rate increase.