Do not sell everything, sell only if its really needed, the long run is in the early stages, for now I think you should hold your coins, because there are signs of a new wave coming.
i guess selling all coins when we see a great opportunity it is necessary, especially bitcoin prices always go up and down so if you can be patient will be able to buy bitcoin back for prepare future.
Yes if its allowing us to make profits then there is nothing wrong in selling them, as we are investing our money in it only to make profits and if we never sell our coins then how we will experience the success of making profits from it.