I think not, in the coming decades or more. Also, since bitcoin has already been available on many storage or node, the only way for bitcoin to fully disappear is to wipe off its data in existence which is highly improbable. As for the user base, it could be decreased too, however I think it wouldn't be possible for the user base to disappear abruptly.
I think users would be also effects when bitcoin dissapear? of course if users not use bitcoinit can make bitcoin dissapear because key of live bitcoin is users itself?
It will disappear if we will not gonna use it anymore, possible reasons are bad reputation due to there are a lot of bitcoin that is lost because of system failure or could be if the government will choose to ban bitcoins for life.