Not with their current mindset.  I think it would be better for Mourinho to start from scratch than to play this current line up.  If he had the full backing of the United board (and Alex Ferguson) then it would be a good idea to let go of a majority of players, especially United's old guard.  Rooney, Smalling and Carrick should be the first ones to go.

Maybe he should have done it during the summer break.  A total revamp from the backroom to the players.  I've read stories of some managers getting rid of workers like janitors or the lady serving the tea because the manager noticed the workers had a losing mentality.