I don't think it's a good idea these days, there are a number of reputable bitcoin casinos here but they've been going for a number of years now, I think money has already been made there.
A lot of the newer casinos where you could potentially make good profit by investing in them are unproven trust wise, I just don't think it's worth the risk.
Yes, you can make a good profit if you invest on a new gambling site. But you should invest only if you know the admin and think that they will not scam otherwise high chance that they may cheat investors. So I suggest even though profit margins are less go with well-trusted sites for these investments instead with new sites.
but you must be careful while investing in casino as casinos in most countries are not legal and people there running illegal casino so you should be careful to avoid in such kind of casino. otherwise you can be scam easily.