I'm pretty sure about 17x reds, 18xreds but 22x is to much for 2x.
Sounds too much but in fact 22x is still possible on x2, afaik there was a player get more than 30x on x2. My worst was 25x long time ago, so dont ever think that it is impossible. Every single roll is independent, when you are so unlucky then you will get something that you think is impossible.
Trust me 22x is very possible on x2 and its one of the largest losses I got about a year ago when I did martingale. I even had a small base bet like 500 or 1000 Sats or so and I didn't think going over 15x was possible but one day disaster stuck and had lost every BTC i had.