I'm pretty sure about 17x reds, 18xreds but 22x is to much for 2x.
Sounds too much but in fact 22x is still possible on x2, afaik there was a player get more than 30x on x2. My worst was 25x long time ago, so dont ever think that it is impossible. Every single roll is independent, when you are so unlucky then you will get something that you think is impossible.
If a player plays this dice game for a longer period then mostly your losing streak will increase, but it can happen at the beginning itself. I usually play dice game manually so once I reach around 6 or 7 losing streaks then will stop my game even though I under loss so didn't experience so many losses in dice yet.
But still it doesn't mean if you are do manually you might not face this losing streak though. I ever experience around 15 losing streak just by manual click and around 33 bet by auto betting. Everything is possible on gambling though, you just need that bad luck wont happen to you