I think Greed is only the big mistake in gambling.
Well greed is the most known thing that let people make mistakes because they get addicted to gambling because of that.
Greed is just normal in human beings it is already in our veins when it comes to money, we can't remove that in our way of thinking. It is cause by dissatisfaction because when we experience winning for awhile we tend to think that we can get so much more if we are going to gamble again. And that is almost everyone's worst mistake which is leading us to lose a lot.