I know I've seen this type of thread probably 5 times already, but I wanted to gauge the interests of people on this forum and see an updated version of it.
I'll start off and say my favorite gambling site has to be Safedice due to the low edge that they have on the site itself.
It depends what kind of games do you like, when I want to bet on sports then cloudbet with its massive welcome bonus seems like the best choice, I also like fairlay since it has better odds, when it comes to binary trading you could try secondstrade, and when it comes to dice I prefer bitvest.