Yes - Pro Miner can connect to any node that supports Ethereum JSON-RPC. It polls eth_getWork to get work items and calls eth_submitWork to submit solutions.

Just choose "external" as the server on the Farm Client tab and enter the IP address and port of your node's RPC endpoint - e.g. http://192.168.1.1:8545.

EDIT: Of course, it supports Stratum connections for pool mining too.