Maybe it's not possible to predict how things will work out no matter how intelligent you are if a system is sufficiently complicated. In which case the bad things that happen are an unfortunate side effect of life and existence.
Maybe its not possible for there to be a perfect system of life without suffering. For example life might not even be able to exist if there are no contrasts in feeling, so maybe there have to be ups and downs.
Maybe we are evolving towards a perfect existence, but to get there we have to wade through some lower evolutionary states.
Maybe things are objectively perfect, because without any danger, challenges or surprise life might be boring (may be absurd given the extremes of suffering, and relative mildness of boredom)
Either way, random or not we are deeply connected to the Universe and all of life.