As in solo PoS mining? Yes, but you will need 100% uptime on your wallet or you risk missing votes / being rewarded.
Otherwise, you can use staking pools. Good list with pool stats at the bottom of the page:
https://dcrstats.com/And if you don't want to handle staking yourself, there's the Evolution pool, which handles buying and staking tickets for you:
https://evolution.dcrstats.com/en