What's on those 2 HD's? If this is a dedicated rig, I'd advice using LinuxCoin from an USB thumbdrive. Its awesome!
- 250GB HDD has Ubuntu 11.04 Desktop x64. I'm switching it to 10.04 Server x64 soon though.
- 3TB HDD is used for network backup. I'm going to create a Samba share and backup my main desktop (Win 7, i7 920, etc) to this drive over my LAN.
I actually purchased a 32GB USB flash drive to run this rig driveless. I ended up not doing so since I found an old drive lying around. Though if I end up picking p a MyOpenPC case - I'll swap to driveless just to save room.
I've heard that Ubuntu persistence is nice - but that it can be slow at times.