After a bit of tweaking, I've settled on the following for my EVGA 1060 6GB SSC card in my main work/gaming PC:

Power target: 61%
Temp target: 90C
GPU offset: +90
Mem offset: +900
Fan target: 45%

Clocks are at ~1900 core and 9600 memory and this nets me ~310 sol/s @ 90W which ends up being around 3.4 Sol/W
The temperature is right around 67C and the fan noise is very quiet

The best thing is I can just work away, watch videos etc. and I barely even notice that it's mining