TBH is anyone certain that MtGox, Bitstamp, and BTC-e aren't owned by the same principals? I know MtGox, Bitstamp, Bitcoincharts and Bitcoinwatch all use Cloudflare and nginx. Are we sure this is a coincidence?
Well and I'm sure they also all use Windows and computers.
[/sarcasm]
If you have high traffic website nginx is the only way. Same goes for cloudflare - there are others but unless you need something specific CloudFlare is the cheapest and at the same time works very well.