It depends on what your work is and if the new venture you are going into are more profitable and proven as a winning concept to replace your
income from your current job. I have friends who
lost their jobs and who are working freelance for Bitcoin and they are struggling at the
moment. { The market is still small }
I would first go into it part-time and then see how it goes, before I leave my current job and go all out into Bitcoin.

I would advise you not to completely burn bridges from a previous job. The fact is that Bitcoin is an alternative and can not be basically with earnings. You need to weigh your chances very much.