I just got into this over the weekend. Let me just say that I was super skeptical at first, but it seems legit so far. (We'll see how it goes when I try to withdraw! ^_^)
Anyway, ETH gambling on the site seems slow, so I'm not seeing much in terms of a return. I deposited and went into the negatives for about a day but slowly climbed out. I'm sitting at about .43%
I noticed there is a lot more BTC bets being made so made a deposit with that currency and have already jumped to a 6% return in a couple days.
So next, I'm going to deposit some LTC despite Twisted's low returns (edit: last week) because I also see a lot of bets being made with it.