This afternoon, I knocked together a simple profitability auto-switcher that works with nvOC and NiceHash:

https://gitlab.com/salfter/nvoc-nicehash-switcher

It might also work if you're mining elsewhere, though profitability is determined by NiceHash (as exposed through their API).  It's a Python script that gathers information about what's profitable and calls shell scripts to reconfigure overclocking settings and launch miners on a per-algorithm basis.  It replaces oneBash for normal operation; oneBash is only needed for initial setup or to add/remove GPUs (it manages /etc/X11/xorg.conf).