Put the directory in the exclude from scanning option. Virus scanners look for "signatures" including some BTC addresses and the block chain will at some point also contain random sequence of characters that will inadvertently trigger it.
It's actually not because of randomness. People have been intentionally embedding viruses (or their signatures) in the blockchain so that antivirus software are triggered.
Does that mean if you whitelist Core wallet in your antivirus program, you leave your Core wallet open to virus? If so, what is the answer?
AVG quarantined my wallet and I had to whitelist it to get back into it.