I do:

TDP: DIFFERS (actual setting means nothing, because some OC cards already have tweaked settings, so 80% tdp for card1 can be 200 watts and for card2 can be 250 watts). Best deal here is 200 watt for 1000 mh/s, so 5mh per watt on skein, but 4 is also OK for me(cheap electricity). Need to adjust manually here.
Voltage: no need to change for beginners.
Memory: -500, it does not have influence on skein algo
Core: DIFFERS (actual setting means nothing, because some OC cards already have tweaked settings ... (C)) For non-OC card it may go up to +300, for OC already it may go up to 120 max. It depends... Need to manually adjust. My cards run at 1900 +- Mhz.

P.S. temp limit I set to 75, and fan is set manually 60-80% depending on the card...