I am running 5 of these boards and do not have any issues. This board appears to have the most PCI lane management features I have ever seen on a motherboard. Be sure your M.2 slots are configured for PCI and not SATA. Also, if you are using a SSD/HDD for nvOC, be sure you are not using a SATA slot that might be conflicting with the M.2 slot. There is a chart for this in the mobo manual. My 2 cents.