Is it anything to be worried about, the deep re-orgs? Anything we could even do something about even if it was a cause for concern, or just something ya gotta roll with?
It's a problem. My games are calculated after one confirmation but some of the reorgs have been a few hundred blocks. I could get scammed by a miner so I have to wait until either the block relaying improves or a malicious miner is done playing around.... But right now the UNO network has one miner with over 51% so I would say it doesn't look healthy to me.
https://chainz.cryptoid.info/uno/#!extraction
Perhaps UNO should explore multialgo to keep the miners honest.
edit: I should also add that any exchange could be scammed the same way, they will probably take some action.