11 hours running,
I have not encountered any issue yet.
I also noticed that this miner is more efficient compared to other miner software out there.

tdp 85%
coreclock 130
memory -502
temp at 61c
fan at 68%

Screenshot:
http://i.imgur.com/BJE4QKI.png

   _________ __ ________
   \_ ___ \__ _ _|__|/ _____/ _____
   / / \ \/\ \/ \/ / / \ ___ / \
   _________\ \ \____\ /| \ \_\ \ Y Y \ __________
   \______ / \/\_/ |__|\______ /__|_| / /
   \/ \/ \/ /
   VC++ 2013 and CUDA 8.0 x64 384.94
CPU:0.62% ChainWorks Industries beta - Version 0.9.8 [10:30:22]
--------------------------------------------------------------------------------
Algo:Skunk | Port: 2000 | NetDiff: 14325.5 | Block: 31600 |
--------------------------------------------------------------------------------
Coin:signatum | POW: 1250 | Estimated coins/day: 232.528 |
--------------------------------------------------------------------------------
Solved: 0 | Diff: 2.5 | Shares: 1511.25 | Rej: 1.08002% | Speed: 162.14M
--------------------------------------------------------------------------------
0.MSI GTX 1080 Ti : Shares: 473.5 | Rej: 6 | Speed: 53.08MH/s|
1.MSI GTX 1080 Ti : Shares: 525 | Rej: 7.5 | Speed: 54.35MH/s|
2.MSI GTX 1080 Ti : Shares: 512.75 | Rej: 3 | Speed: 54.49MH/s|
--------------------------------------------------------------------------------
0.MSI GTX 1080 Ti : T:59C | F:66% | P:238W | I: 24.0 | Core:1932Mhz |
1.MSI GTX 1080 Ti : T:61C | F:68% | P:228W | I: 24.0 | Core:1913Mhz |
2.MSI GTX 1080 Ti : T:65C | F:72% | P:222W | I: 24.0 | Core:1913Mhz |
--------------------------------------------------------------------------------
[10:26:25]Share: 3aa75b9e | [02:45:50][GPU1]:Invalid nonce
[10:26:30]Mean netDiff: 18032.2 | [03:50:17][GPU1]:Job not found (=stale
[10:26:40]Mean netDiff: 17903.9 | )
[10:27:05]Share: e19d06a6 | [06:35:11][GPU0]:Invalid nonce
[10:27:10]Mean netDiff: 17822.9 | [07:14:05][GPU1]:Job not found (=stale
[10:27:40]Mean netDiff: 17752.4 | )
[10:28:20]Mean netDiff: 17690.9 | [08:44:51][GPU1]:Job not found (=stale
[10:29:30]Mean netDiff: 17534.8 | )
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Scan time: 30s | DCs: 0 | User:----- | Conn:0d 11:16:23 | Latency:287ms