Each instance just needs to listen on a different port.
use the -mport flag and set a different port for each instance.
Thanks olaf_d !
So it would end up looking like this?:
NsGpuCNMiner.exe -o ssl://somepool.somewhere:80 -u WALLET_ADDRES -p x -di 01 -mport 3300
NsGpuCNMiner.exe -o ssl://somepool.somewhere:80 -u WALLET_ADDRES -p x -di 2 -mport 3301
NsGpuCNMiner.exe -o ssl://somepool.somewhere:80 -u WALLET_ADDRES -p x -di 3 -mport 3302