Hi Claymore
As you can see from the other user also the exact same issue.
i thought it might have been the board but he is using a asus board and i am using a biostar board.
exact identical problem.
My Biostar is working right with 8 AMD + 4 Nvidia at the same time on Windows 10 x64.
Just two claymore runnning, first with the 8 AMD and the second with 4 Nvidia.
https://cdn.pbrd.co/images/GH7NHsF.png