I suppose you want to run the process without the need to keep open the terminal? In that case you can use "screen". For example  "screen -d -m -S p2pool ~/p2pool/run_p2pool.py". This will run the process in a seperate screen with the name p2pool. You can switch to the screen by using "screen -r p2pool", and detach from it using first Ctrl + A and subsequently Ctrl + D. Don't use Ctrl + C when you have retached the screen because that will terminate the process.

If you want a GUI or so, I don't think there is one (I might be wrong. I run mine on Ubuntu Server so I only use command line). If you want statistics of your miners and stuff like that, you can get those from within your browser by going to http://(ip adress of node on local network):9332/. More info can be found on http://p2pool.in/

I hope this answers your question.