Binaries with pypy are impossible. In order to use pypy, you need to run from source.

pypy uses a TON of RAM. v17 does not have the optimizations I made on my branch to reduce RAM usage by around 4x. Consequently, you can expect the RAM usage on pypy v17 to grow up to around 8 GB. Unless you have 16 GB on your node, running CPython with v17 is probably a better idea.

If you use v33 (my code -- https://github.com/jtoomim/p2pool/tree/1mb_segwit), then pypy is definitely recommended, as the RAM usage is more manageable (around 3-4 GB, despite handling around 2x as many transactions).