1) Ensure you save enough off that to pay taxes.  If you are in the US, you can bet Uncle Sam is going to want 30% of that.

2) 50k-20k = about 35k to invest

3)  BTC, ETH, XMR, NEO - do equal portions.  wait.  rebalance as needed.  maybe take profits and put into some specultive ipo's or such.