Another question I have deals with the hashrates defined in the Algorithms or Profit Profiles. When we manually put in the hashrates or use the really awesome new benchmarking feature... should the rates defined there be a single card or the entire rig? Does AM extrapolate that I have 6 cards and use the multiple rate when determining if switching to a different algorithm should be done?
As long as your benches are all the same--pegged for one card or pegged for six--it doesn't much matter. Personally I have a separate profile for my 1070 rig as they actually hash slightly different from my 1080 Ti rigs. Each set of my benches are pegged to 1x of that card.
After I posted that, I thought about it for a minute and realized the same thing. I also have separate benchmarked profiles for my 1070s and 1080tis. I think the issue that someone may run into is if they have a rig full of mixed cards. It's not as easy or clean to define for someone who has a mixed AMD and nvidia rig for instance. The neat thing about Awesome Miner, is that you can deal with these situations. It takes a little cleverness though.
You could setup two managed miners to point to the same host, and set the managed software to only use GPU 0,1,2 in the custom command line settings (applying an AMD profit profile), and then another managed miner to use managed software to only use GPU 3, 4, 5 (and applying an nvidia profit profile).
Of course, the mining software has to support targeting specific GPUs at the command line level, and there may be other ways of dealing with mixed rigs that I haven't thought of off the top of my head.