However, the reason I made these CPU improvement changes was in the hope that it would allow people to run CPython on medium-speed CPUs without crazy orphan rates.
config is Windows 10 64Bit

A 2.0 GHz A10 is not what i would call a medium-speed CPU, unfortunately. Sure, it might have 4 cores, but Python is effectively single-threaded, so that doesn't help at all. Pre-Ryzen AMD chips have poor single-threaded performance, so a 2 GHz A10 is equivalent in performance to a roughly 1.3 GHz Core i3 (if such a thing existed). I wish I could get p2pool to run nicely on such a CPU, but I'm afraid that's out of reach at the moment.
You've got plenty of RAM, so I think you can get it to work decently if you go through the steps I described to get Pypy running on Windows.
Also, if you could run p2pool with the --bench option, that would make the log file much more useful to me.