I run a 2 rx 470s, 1 rx570, 1 rx 480, and 2 GTX 1070s and its fine.  You have to figure out which algo you are running that causing the amd cards to crash when it runs.  It takes quite a bit of playing or just turn off the algos that you know you don't need.  Dagger crashes my rig due to my overclocks.