Maybe it depends on how often you use the Personal Computer.

Avast is great for some viruses.
Kasperky is great for blocking harmful viruses coming from games.
ESET is a good all-around antivirus.
Webroot is good for blocking websites.

There are also antiviruses for Flashdrives. SMADAV and USB FIX is useful against this viruses.

For now im only using Malwarebytes and some times Windows Defender.